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The service is now available in DC, NYC, Chicago, Los Angeles, Miami, San Francisco, and Dallas.
The Uber iPhone/Android app pulls location data from your phone and Foursquare, and allows you to enter in your destination, and provides you an estimated fare before booking the service and charging your credit card. If you don't have a smartphone you can log in using m.uber.com. Its that simple, no cash, no hassle, no tip.